The Effect of Sirolimus on the Pharmacokinetics of Tacrolimus

Status Recruiting

Clinical Trial Summary

The purpose of this study is to understand whether the pharmacokinetics of tacrolimus is influenced by the concurrent use of sirolimus.

Clinical Trial Description

The controlled clinical trial held in NTUH in 2001 revealed that the bioavailability of tacrolimus when combined with sirolimus is lower than that reported in the literature where tacrolimus was not combined with sirolimus. To determine if the difference was due to the drug interaction between sirolimus and tacrolimus, a controlled clinical trial was proposed.

The purpose of this study is to understand whether the pharmacokinetics of tacrolimus is influenced by the concurrent use of sirolimus. ;

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

Kidney Transplantation

Clinical Trial Details

NCT number	NCT00166829
Study type	Interventional
Source	National Taiwan University Hospital
Contact	Meng-Kun Tsai, MD, PhD
Phone	886-2-23123456
Email	mark9@ha.mc.ntu.edu.tw
Status	Recruiting
Phase	Phase 4
Start date	May 2004

View Details

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