Bicarbonate Administration in Kidney Transplant Recipients

Status Completed

Clinical Trial Summary

Metabolic acidosis is associated with vascular endothelial dysfunction and is a common complication in patients who have received a kidney transplant. Kidney transplant recipients (KTR) with lower serum bicarbonate levels, even within the normal range, have an increased risk of graft loss and mortality. The investigators propose a prospective, double-blind, randomized, placebo-controlled, 18-week crossover pilot study to examine the effects of sodium bicarbonate on vascular endothelial function, graft function, and cognitive function in 20 KTR patients.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03428464
Study type	Interventional
Source	University of Colorado, Denver
Contact
Status	Completed
Phase	N/A
Start date	December 5, 2018
Completion date	March 25, 2020

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04369456` - Blood Biomarkers as Predictors of COVID-19 Disease Progression in Recently Infected Kidney Transplant Patients	N/A
Recruiting	`NCT06001320` - De-novo Initiation of Letermovir vs Valganciclovir for Cytomegalovirus Prophylaxis in AA Kidney Trans Recip	Early Phase 1
Withdrawn	`NCT04560582` - Immunosuppression Reduction in Failed Allograft Guided by cfDNA
Not yet recruiting	`NCT05782543` - Renal Ex Vivo Warm Advanced Resuscitation Through Machine Perfusion	N/A
Completed	`NCT03996551` - ExeRTiOn2- The Weight Gain Prevention Exercise in Renal Transplant Online Study	N/A
Recruiting	`NCT05081141` - HHV8 and Solid Organ Transplantation
Recruiting	`NCT04508907` - A Study to Evaluate Preemptive Therapy in Hepatitis C (HCV) Organ Transplant Recipients	Phase 4
Recruiting	`NCT06440330` - Define Predictors for Posttransplant Diabetes Mellitus Study
Not yet recruiting	`NCT06025240` - Expanding the Scope of Post-transplant HLA-specific Antibody Detection and Monitoring in Renal Transplant Recipients
Recruiting	`NCT04713774` - Bone Density and Vascular Calcifications Evolution After Renal Transplant
Active, not recruiting	`NCT05483725` - Immunological Safety and Effectiveness of the First Booster Dose of mRNA Vaccines Against COVID-19 in Kidney Transplant Recipients.
Recruiting	`NCT06095492` - Effect of Empagliflozin vs Linagliptin on Glycemic Outcomes,Renal Outcomes & Body Composition in Renal Transplant Recipients With Diabetes Mellitus	N/A
Active, not recruiting	`NCT04207177` - Immunosuppressive Drugs and Gut Microbiome: Pharmacokinetic- and Microbiome Diversity Effects	Phase 4
Recruiting	`NCT03410654` - Assessment of Cognitive Function Before and After Conversion From Immediate Release Tacrolimus to Envarsus XR.	Early Phase 1
Completed	`NCT03373266` - Serun Fluoride and Kidney Transplant	Phase 2
Completed	`NCT04835948` - Efficacy of Single Dose Anti-thymocyte Globulin in the Modulation of T Lymphocytes in Kidney Transplantation
Not yet recruiting	`NCT04514666` - VOCs in Kidney and Liver Transplants	N/A
Recruiting	`NCT03373500` - Effect of Dietary Salt Reduction on Blood Pressure in Kidney Transplant Recipients	N/A
Recruiting	`NCT05900401` - Delayed Tolerance Through Mixed Chimerism	Phase 1/Phase 2
Not yet recruiting	`NCT05166460` - Novel Cooling Device for the Elimination of Warm Ischemia During Renal Transplantation	N/A