Kidney Transplantation Clinical Trial
Official title:
The Influence of ABCB1、CYP3A4、CYP3A5、POR Genetic Polymorphism and Other Factors on Tacrolimus Blood Concentration
The purpose of the study is to identify factors that may influence tacrolimus (TAC) pharmacokinetics, and the impact of gene polymorphism (ABCB1, CYP3A4, CYP3A5, POR) on pharmacokinetics of TAC in Taiwanese.
TAC is one of the most important immunosuppressive agents for organ transplantation. In some
patients the dose and concentration of TAC are difficult to adjust because of its narrow
therapeutic index and variable pharmacokinetics.
Many factors affect the pharmacokinetics of TAC. Literature suggests that ABCB1, CYP3A4,
CYP3A5, POR gene polymorphisms may affect the pharmacokinetics of TAC. In addition, the
distribution of TAC is affected by hematocrit and albumin concentrations. The
pharmacokinetics of TAC may also be affected by total protein, total bilirubin, creatinine,
AST, ALT, gender, age, drug interactions, and so on.
This study intends to analyze the influence of various factors, including drugs, on the
pharmacokinetics of TAC.
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Observational Model: Case-Only
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