Kidney Transplantation Clinical Trial
Official title:
Prevention of Skin Cancer in High Risk Patients After Conversion to a Sirolimus-based Immunosuppressive Protocol
Transplant recipients have a high risk to develop skin malignancies. This effect depends on
the one hand on the immunosuppressive drugs themselves (i.e., azathioprine) and relates on
the other hand on the dosage (i.e., calcineurin-inhibitors). Based on the encouraging
results of previous, retrospective studies on patients treated with Sirolimus (SRL), these
patients should be switched to an immunosuppressive regime including SRL, decreasing the
dosage of calcineurin-inhibitors or converting from former immunosuppression. A conversion
to a SRL-based therapy is effective in immunosuppression and safe regarding graft and
patient survival.
This study was designed to assess whether a switch to a SRL-immunosuppressive therapy
decreases the incidence/reoccurrence of skin neoplasm.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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