Oxalate-Driven Host Responses in Kidney Stone Disease

Status Recruiting

Clinical Trial Summary

This study is looking to understand the role of oxalate on kidney stone development and immunity. This study will enroll healthy participants and participants with calcium oxalate kidney stones (CaOx KS). Participants will be in this study for about 3 weeks, consume controlled diets, and provide blood and urine specimens.

Clinical Trial Description

The purpose of this longitudinal study is to examine the effects of dietary oxalate on nanocrystalluria and the immune system. Oxalate is a small molecule found in plants and plant-derived food. It has been shown that meals containing high amounts of oxalate can increase urinary oxalate excretion, which is a risk factor for calcium oxalate kidney stones (CaOx KS). Small increases in oxalate can stimulate urinary crystals to form which can elicit an immune response. This study consists of having healthy subjects and patients with CaOx KS consume both low and oxalate enriched diets to evaluate the effect of oxalate on urinary crystals and immune responses. Participants will receive a low or high oxalate diet for 4 days prior to having a wash-out period for 6 days. Participants will then crossover to the opposite oxalate diet for four more days. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05417568
Study type	Interventional
Source	University of Alabama at Birmingham
Contact	Tanecia Mitchell, PhD
Phone	(205) 996-2292
Email	taneciamitchell@uabmc.edu
Status	Recruiting
Phase	N/A
Start date	May 19, 2023
Completion date	May 30, 2027

View Details

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