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Prevalence of Hypotension Associated With Preload Dependence During Continuous Renal Replacement Therapy — PRELOAD-CRRT  

Kidney Injury Clinical Trial

Official title:
Prevalence of Hypotension Associated With Preload Dependence During Continuous Renal Replacement Therapy

Clinical Trial Summary

Per-dialytic hypotension is common in Intensive Care Unit patients under continuous renal replacement therapy, and occurs in nearly 50% of the patients. To date, there is a lack of study having characterized the underlying mechanism of hypotension in this setting. New diagnostic methods are now available with high reliability to identify hypovolemia as the underlying cause of hypotension, among which change in cardiac index during passive leg raising may be the less affected by restrictive validity criteria. A change in cardiac index greater than 10% during this test is highly predictive of preload dependence, i.e the probability than cardiac index will increase if cardiac preload increases. The aim of this study is then to identify, among hypotensive episodes occurring during renal replacement therapy in Intensive Care Unit patients, the percentage of episodes related to preload dependence as identified by passive leg raising.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03139123
Study type Observational
Source Hospices Civils de Lyon
Contact
Status Completed
Phase
Start date May 18, 2017
Completion date November 21, 2020
View Details
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