Kidney Injury Clinical Trial
Official title:
Advance Targeted Transfusion in Anemic Cardiac Surgical Patients for Kidney Protection: A Proof of Concept Pilot Study
One of the major complications of heart surgery is kidney injury, which occurs in up to 30%
of patients and is associated with poor outcomes including death. We have found that
patients whose hemoglobin concentration before surgery is lower than normal (i.e., are
anemic) are at particularly high risk for this complication, likely because their hemoglobin
concentration drops to very low levels during surgery, which reduces delivery of oxygen to
the kidneys, increases blood loss, and necessitates blood transfusions. We and others have
shown that these events are individually harmful to the kidneys, and can lead to kidney
injury. We believe that we can prevent these events from occurring, and as a result reduce
the risk of kidney injury, if we transfuse anemic patients at least 1 day before surgery
rather than during surgery.
In anemic patients undergoing cardiac surgery, prophylactic transfusion of red blood cells
(RBCs) before surgery will reduce the risk of acute kidney injury (AKI) after surgery by
mitigating three inter-related risk factors for AKI.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention
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