A Study in Participants With End-Stage Renal Disease

Status Completed

Clinical Trial Summary

The purpose of this trial is to explore the effect of LY2127399 on those antibodies that are a barrier to kidney transplant. Transplantation is currently the definitive treatment for End-Stage Renal Disease (ESRD), providing prolonged survival and improved quality of life.

Clinical Trial Description

In this study, LY2127399 will be tested as a potential treatment to reduce the blood proteins in some participants with ESRD. These proteins are called alloantibodies and are made by the body to react with other proteins on cells of transplanted organs called human leukocyte antigen (HLA) proteins. When a participant has these antibodies, they are referred to as HLA-presensitized. Often the presence of these antibodies, categorized by a method called the panel reactive antibody (PRA), can make a person ineligible to receive a transplant or experience very long wait times on the kidney transplant waiting list. Therefore the need to reduce the antibodies is significant for the successful treatment of ESRD. This study will treat ESRD participants for 6 months with LY2127399 and measure PRA levels for a total of 18 months. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01200290
Study type	Interventional
Source	Eli Lilly and Company
Contact
Status	Completed
Phase	Phase 2
Start date	April 2011
Completion date	March 2014

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03246984` - VALUE- Vascular Access Laminate eUropean Experience. A Post Market Surveillance Study to Assess the Safety and Effectiveness of VasQ	N/A
Completed	`NCT02922361` - Spending and Outcomes for Complex Medicare Advantage Patients
Completed	`NCT02235571` - iChoose Decision Kidney Aid for End-Stage Renal Disease Patients	N/A
Completed	`NCT01922843` - A Phase 2 Study of an Oral Vitamin D Compound (DP001) in Secondary Hyperparathyroidism in Patients on Hemodialysis	Phase 2
Completed	`NCT01930396` - Use of Tinzaparin for Anticoagulation in Hemodialysis	Phase 4
Completed	`NCT01933789` - Improving Communication About Serious Illness	N/A
Not yet recruiting	`NCT01674660` - Factors Associated With Interdialytic Blood Pressure Variability in Maintenance Hemodialysis Patients	N/A
Completed	`NCT01209403` - Insulin-like Growth Factor (IGF-I) in Hemodialysis Patients	Phase 4
Not yet recruiting	`NCT01157260` - The Effects of AST-120 on Endothelial Dysfunction in Patients With Chronic Kidney Disease	Phase 4
Completed	`NCT00753116` - Renal Denervation in End Stage Renal Disease Patients With Refractory Hypertension	Phase 1
Recruiting	`NCT00532688` - N-Acetylcysteine in Heart Failure With Coexistent Chronic Renal Failure	Phase 2/Phase 3
Completed	`NCT00528788` - How Vitamin D Analogues Affect Endothelial Cells in Patients on Dialysis	Phase 4
Completed	`NCT00534144` - Comparison Between Effects of Two Iron Preparations on Protein in the Urine	Phase 1
Completed	`NCT00226902` - Vascular Reactivity in Kidney Disease Patients	N/A
Completed	`NCT00382044` - Audit of the Effect of Changing From IV to SC Administration of ESA's in Haemodialysis Patients	N/A
Recruiting	`NCT00235287` - Pulse Wave Velocity, Pulse Wave Morphology and Blocking of the Reninangiotensin System in Patients With Chronic Kidney Disease	Phase 4
Completed	`NCT00224081` - DRIVE Trial (Dialysis Patients' Response to Intravenous [IV] Iron With Elevated Ferritin)	Phase 4
Completed	`NCT00071214` - Study to Evaluate the Effectiveness of StaphVAX in Adults on Hemodialysis	Phase 3
Completed	`NCT00049907` - Cardiac and Renal Disease Study (CARDS)	N/A
Completed	`NCT00006297` - Risk Factors for CV Disease in a Dialysis Cohort	N/A