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Left Ventricular Hypertrophy and Spironolactone in End Stage Renal Disease

Kidney Failure, Chronic Clinical Trial

Official title:
Cardiac Magnetic Resonance Imaging in Hemodialysis Patients

Clinical Trial Summary

The hypothesis of this trial is to assess the effect of spironolactone on heart size and mass

Clinical Trial Description

Dialysis patients have significant morbidity and mortality associated with left ventricular hypertrophy and cardiac failure. Aldosterone may have an important role in the development of myocardial hypertrophy and remodeling. Animal studies have demonstrated beneficial effects of aldosterone antagonists on myocardial hypertrophy, and human studies have shown significant survival benefit in a non-dialysis population with congestive heart failure. This study evaluates the effect of spironolactone (an aldosterone receptor antagonist) on cardiac hypertrophy in the end-stage renal disease population. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00548912
Study type Interventional
Source West Penn Allegheny Health System
Contact
Status Withdrawn
Phase Phase 4
Start date October 2007
Completion date October 2008
View Details
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