Kidney Failure, Acute Clinical Trial
Official title:
EValuation Of NGAL in Early and eVolving Acute kidnEy Injury
Some patients who undergo cardiovascular surgery requiring cardiopulmonary bypass will develop a kidney injury following their surgery. The purpose of this study is to take a blood sample from patients before they have this type of surgery and then at nine time points after their surgery to test their plasma for a biomarker called NGAL and compare the NGAL levels to their creatinine levels. We hypothesize that NGAL is an earlier marker for kidney injury than creatinine.
Approximately 350 adults scheduled to undergo cardiac surgery involving the use of
cardiopulmonary bypass will be enrolled. Blood samples will be obtained from all patients in
the study for future measurement of both plasma NGAL and plasma creatinine levels in the
same sample at each of nine time points.
Blood samples for later assessment using the Triage NGAL Test will be processed to plasma at
the clinical site, frozen and shipped to Biosite for storage. Testing with the Triage NGAL
Test will be conducted at Biosite by trained laboratory personnel. The results of these
assessments will be blinded to the medical team during the study and will not impact the
medical management of the patient.
The medical team caring for each study patient should obtain clinical laboratory tests per
their usual post-operative routine and manage the patient accordingly. Any serum creatinine
measurements obtained by the site as part of this routine care both pre-operatively and
through Day 10 post-operatively will be recorded as well as any additional post-operative
renal insults, the development of oliguria, the need for a nephrology consultation,
initiation of dialysis and mortality will also be recorded through Day 10.
;
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00982527 -
Fenoldopam in Pediatric Cardiac Surgery
|
Phase 3 | |
| Completed |
NCT00908843 -
Prevention of Contrast Induced Nephropathy (NIC) by Intravenous Versus Oral Rehydration
|
N/A | |
| Completed |
NCT00654992 -
Effect of Erythropoietin (EPO) in Kidney After Cardiac Surgery
|
Phase 2/Phase 3 | |
| Completed |
NCT05407272 -
Explore the Sharing Model Intervene to Improve the Knowledge, Attitudes, Service Intentions and Service Start-up Effects of the Eight Major Non-cancer Disease End-stage Caregivers on Well-being and Palliative Care
|
N/A | |
| Not yet recruiting |
NCT05399420 -
Study of Kidney Circulating Cell-free DNA in Patients With Acute Kidney Failure
|
||
| Recruiting |
NCT04334707 -
Kidney Precision Medicine Project
|
||
| Completed |
NCT04072432 -
A Study of RBT-3 in Healthy Volunteers and Volunteers With Stage 3-4 Chronic Kidney Disease
|
Phase 1 | |
| Recruiting |
NCT00230412 -
Study of Heat Shock Proteins as Prognostic Factor of Acute Renal Failure in Children (HSP-Study)
|
N/A | |
| Completed |
NCT00148044 -
Uremic Toxins of Patients With Acute Kidney Failure
|
N/A | |
| Active, not recruiting |
NCT04450095 -
Effects of Endothelin Receptor Antagonist on Ischemic Kidney Injury During Nephron Sparing Surgery
|
Phase 2 | |
| Terminated |
NCT05747053 -
Personalization of Immunosuppressive Treatment for Organ Transplant Recipients
|
||
| Completed |
NCT03353389 -
Review of Trend in Incidence and Characteristics of Hospital-acquired Acute Kidney Injury in Hospital Selayang
|
||
| Completed |
NCT03727581 -
Ultrasound for Guidewire Detection
|
||
| Completed |
NCT00912184 -
Study Comparing High Cut-off Haemofiltration With Standard Haemofiltration in Acute Renal Failure
|
Phase 1/Phase 2 | |
| Recruiting |
NCT00522756 -
Preventing Acute Renal Failure After Cardiac Surgery in High Risk Patients Using Sodium Bicarbonate Therapy
|
Phase 3 | |
| Completed |
NCT00484354 -
Use of Bicarbonate to Reduce the Incidence of Acute Renal Failure After Cardiac Surgery
|
Phase 2 | |
| Terminated |
NCT00316576 -
Angiotensin-Converting Enzyme Polymorphism and Acute Renal Failure (ECAREA)
|
N/A | |
| Completed |
NCT00122018 -
An Investigation of N-acetylcysteine and Fenoldopam as Renal Protection Agents for Cardiac Surgery
|
Phase 2 | |
| Unknown status |
NCT01359722 -
N-acetylcysteine to Prevent Renal Failure
|
N/A | |
| Completed |
NCT00286273 -
Safety and Efficacy of the Use of Regional Anticoagulation With Citrate in Continuous Venovenous Hemofiltration
|
Phase 4 |