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Uric Acid and the Endothelium is CKD

Kidney Disease Clinical Trial

Official title:
Is Uric Acid a Mediator of Endothelial Dysfunction in Patients With Chronic Kidney Disease?

Clinical Trial Summary

This study will test the hypothesis that uric acid impairs the function of vessels in patients with kidney disease

Clinical Trial Description

The purpose of the study is to understand the effect of lowering serum uric acid levels on vascular function in individuals with chronic kidney disease by comparing the effects of:

1) Allopurinol therapy and 2) Placebo.

Patients will receive: 3 month study drug (either allopurinol or placebo), with assessment of serum uric acid levels and vascular function. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01228903
Study type Interventional
Source University of Colorado, Denver
Contact
Status Active, not recruiting
Phase N/A
Start date October 2010
Completion date September 2016
View Details
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