Testosterone Replacement Therapy in Advanced Chronic Kidney Disease

Status Completed

Clinical Trial Summary

Muscle wasting is common in advanced chronic kidney disease (CKD) and adversely affects morbidity and mortality. In 2/3 of males with advanced CKD serum testosterone (TT) levels are reduced, and likely contributes to the wasting. As TT in relatively safe physiologic replacement doses, increases muscle mass in otherwise normal TT deficient subjects, we hypothesize that physiologic TT replacement will be effective in preventing and treating the loss of muscle mass and function in CKD patients, will improve quality of life and may reduce some cardiovascular disease (CVD) risk factors.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00645658
Study type	Interventional
Source	Stanford University
Contact
Status	Completed
Phase	N/A
Start date	August 2007
Completion date	August 2010

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03246984` - VALUE- Vascular Access Laminate eUropean Experience. A Post Market Surveillance Study to Assess the Safety and Effectiveness of VasQ	N/A
Completed	`NCT03545113` - Graft-first Versus Fistula-first in Older Patients With End-stage Kidney Disease	N/A
Recruiting	`NCT05100017` - Methocarbamol vs Oxybutynin for Management of Pain and Discomfort S/P Ureteroscopy Procedure	N/A
Recruiting	`NCT04559321` - Holmium Vs Trilogy Kidney Stones GUY's 1-2	Phase 3
Recruiting	`NCT05036850` - China Kidney Patient Trials Network
Completed	`NCT04037436` - Functional Exercise and Nutrition Education Program for Older Adults	N/A
Active, not recruiting	`NCT01529658` - Renal Hypothermia During Partial Nephrectomy	N/A
Completed	`NCT01679587` - Dose Escalation Study to Investigate Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BAY85-3934 in Subjects With Chronic Kidney Disease (CKD)	Phase 1
Completed	`NCT01155141` - Idiopathic Focal Segmental Glomerulosclerosis (FSGS) and Treatment With ACTH	Phase 4
Completed	`NCT00755690` - Study of Dietary Phosphate and Mineral Homeostasis in Early Chronic Kidney Disease	N/A
Recruiting	`NCT05759754` - Effects of Traditional Chinese Medicine (GSJYF) in Children With Inherited Proteinuric Kidney Disease	N/A
Completed	`NCT03213158` - Ixazomib for Desensitization	Phase 2
Active, not recruiting	`NCT02237352` - Mechanisms of Diabetic Nephropathy in Ecuador
Recruiting	`NCT06067867` - Kidney and Pregnancy Registry
Recruiting	`NCT04110080` - Enhanced Recovery After Surgery in Kidney Transplant Donors	N/A
Active, not recruiting	`NCT04876963` - HOLT-ED: Holter-monitoring in End-stage Renal Disease
Enrolling by invitation	`NCT05324878` - Honoring Individual Goals and Hopes: Implementing Advance Care Planning for Persons With Kidney Disease on Dialysis
Not yet recruiting	`NCT03899298` - Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions	Phase 1
Active, not recruiting	`NCT04631965` - Healthcare Transition of Adolescents With Chronic Health Conditions
Completed	`NCT03394859` - Electronic Medical Records and Genomics (eMERGE) Phase III