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NCT00005767 Clinical Trial

Dynamic Aspects of Amino Acid Metabolism

Kidney Diseases Clinical Trial

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00005767
Other study ID # NCRR-M01RR00109-0740
Secondary ID M01RR000109
Status Recruiting
Phase N/A
First received June 1, 2000
Last updated June 23, 2005

Study information
Verified date December 2003
Source National Center for Research Resources (NCRR)
Contact Dwight Matthews, Ph.D.
Phone 1-802-646-8114
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

This protocol seeks to define aspects of intestinal and hepatic uptake and metabolism of several amino acids. The major hypothesis to be tested is that the splanchic bed (intestine and liver) conserves essential amino acids and metabolites while synthesizing and metabolizing nonessential amino acids. The aims of the study include defining the relative roles of enteral and hepatic extraction/metabolism in the disposition of glutamate, alanine, methionine and other amino acids. Emphasis will also be placed on studies of the transamination of alpha-ketoisocaproic acid (KIC) to leucine since this reaction is of potential importance in the design of nutritional regimens for patients with renal disease.

Recruitment information / eligibility
Status Recruiting
Enrollment 0
Est. completion date
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years to 55 Years
Eligibility Inclusion Criteria:

- normal weight-for-height weight 50-80 kg

- normal physical activity

- no significant medical history

- healthy by medical exam and lab blood testing

Exclusion Criteria:

- subjects who exercise vigorously

- subjects who smoke

Study Design

Observational Model: Natural History, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Locations
Country Name City State
United States University of Vermont Burlington Vermont

Sponsors (1)
Lead Sponsor Collaborator
National Center for Research Resources (NCRR)

Country where clinical trial is conducted

United States, 

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