Kidney Disease Clinical Trial
Official title:
Arterial Stiffness and Decreased Bone Buffering Capacity in Hemodialysis Patients
Renal patients have an increased risk for cardiovascular complications. There is also
increased vascular calcification and bone metabolism is similarly abnormal in patients with
chronic kidney disease.
In dialysis patients frequent episodes of hypercalcaemia occur. In a healthy bone structure
those episodes of hypercalcemia are buffered by the bone. The absence of bone buffering
capacity in dialysis patients can be a mechanism for vascular calcifications.
Study hypothesis.
Patient with a higher ∆ Calcium (Calcium post - Calcium pre) have a diminished bone buffering
capacity indicative for adynamic bone disease compared with patients with smaller ∆ Calcium.
This may result in higher extraosseous calcification and higher pulse wave velocity
∆ PTH/∆ Calcium may reflect the sensitivity and density of the calcium receptors; this may
reflect parathyroid "health"
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