Kidney Cancer Clinical Trial
Official title:
Uro-DNA Collection for Expanded Genome-Wide Association Study (GWAS) of Renal Cell Carcinoma (RCC) (Uro-DNA - GWAS)
In the last decade, investigators from the Department of Cancer Epidemiology and Genetics
(National Cancer Institute, USA) have conducted genome-wide association (GWAS) studies of
renal cell carcinoma.
Dr. Mark PURDUE and Dr. Stephen CAHNOCK (Department of Epidemiology of Cancer and Genetics,
NCI) propose to expand their genome-wide association study (Expanded GWAS) by genotyping
approximately 10,000 additional cases of kidney cancer patients, in collaboration with US
institutions, South-American and European.
This study describes the participation of the French Kidney Cancer Research Network (UroCCR)
in the Expanded GWAS research, under the coordination of Professor BERNHARD (Bordeaux
University Hospital).
The aim of the Expanded GWAS study is to better understand the role of common genetic
variants in susceptibility to renal cell carcinoma (RCC).
The participation of the French UroCCR network consists in completing the bio-collection of
the UroCCR cohort by preserving constitutional DNA and to provide DNA samples to the US NCI
team.
This will increase the number of samples for meta-analysis and contribute to better identify
clear cell kidney cancer susceptibility loci.
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