Kidney Cancer Clinical Trial
Official title:
Investigating the Frequency of Loss of Imprinting Across a Birth Cohort and the Link DNA Methylation Plays
RATIONALE: Studying samples of blood and tissue from newborns and from patients with cancer
in the laboratory may help doctors learn more about changes that occur in DNA and identify
biomarkers related to cancer.
PURPOSE: This research trial studies cord blood and placenta tissue from newborns, and tumor
tissue samples from patients with Wilms tumor.
OBJECTIVES:
- What is the frequency of loss of imprinting at birth (in the cord blood and placenta)
in a relatively healthy birth cohort?
- Does deoxyribonucleic acid (DNA) methylation levels at imprinting genes have a direct
association to the gene expression?
OUTLINE: Archived tumor tissue, cord blood, and placenta samples are analyzed for DNA
methylation, single nucleotide polymorphism, and gene expression by polymerase chain
reaction (PCR), pyrosequencing, and quantitative real-time PCR. Information regarding gender
and age of the samples are also collected, if possible.
;
Observational Model: Case Control, Time Perspective: Retrospective
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