Kidney Cancer Clinical Trial
Official title:
Determination of the Frequency of BRG1 and BRM Loss in Rhabdoid Tumors
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may
help doctors learn more about changes that occur in DNA and find biomarkers related to
cancer. It may also help doctors find better ways to treat cancer.
PURPOSE: This research trial studies gene expression in samples from patients with rhabdoid
tumors.
OBJECTIVES:
- To determine if BRM is silenced in the majority, if not all, rhabdoid tumors by
immunohistochemistry in primary tumors.
- To determine if BRG1 is silenced in the majority, if not all, rhabdoid tumors by
immunohistochemistry in primary tumors.
- To determine if GATA1 and/or HDAC2 is overexpressed in the same tumors that lack BRM
expression.
- To determine if BRM promoter polymorphisms correlate with loss of BRM expression in
primary rhabdoid tumors.
- To determine how BRG1 is silenced in primary rhabdoid tumors by sequencing BRG1 exons
in genomic DNA derived from frozen samples.
OUTLINE: Archived tumor tissue samples are analyzed for BRM, BRG1, GATA1, and/or HDAC2
expression by immunohistochemistry. BRM- and BRG1-negative samples are also analyzed.
;
Observational Model: Case-Only, Time Perspective: Retrospective
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