Kidney Cancer Clinical Trial
Official title:
Endogenous DNA Transposition in Rhabdoid Tumors
RATIONALE: Studying samples of tissue from patients with rhabdoid tumors in the laboratory
may help doctor learn more about changes that occur in DNA and identify genes related to
cancer.
PURPOSE: This research trial studies biomarkers in samples from young patients with rhabdoid
tumors.
OBJECTIVES:
- To investigate the expression and function of transposons in 50 primary rhabdoid
tumors.
OUTLINE: Freshly frozen rhabdoid tumors will be studied using fluorescence in situ
hybridization (FISH) and polymerase chain reaction (PCR) to establish the genomic location
of transposons. Protein expression in rhabdoid tumor tissue microarrays is also analyzed.
;
Observational Model: Case-Only, Time Perspective: Retrospective
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