Kidney Cancer Clinical Trial
Official title:
Development of a Blood Test of Anti-IMP3 Autoantibody and Serum MicroRNA Signature for the Detection of Renal Cell Carcinoma With Metastasis and Metastatic Potential
This research trial studies the development of a blood test for detecting anti-insulin-like growth factor II mRNA binding protein 3 (anti-IMP3) antibody and micro ribonucleic acid (microRNA) in patients with renal cell carcinoma (RCC) that has spread to other parts of the body (metastatic) or is limited to the tissue or organ where it began (localized). Anti-IMP3 is a tumor marker that can be detected in many human cancers, including RCC and is likely to be present in the serum (blood) of patients with metastatic or localized RCC. Alterations in microRNA expression has also shown to play a critical role in cancer progression and may be a promising biomarker for patients with RCC. Developing a blood test for anti-IMP3 antibody and microRNA in serum and tissue samples of patients in the laboratory may help doctors find and diagnose RCC earlier, find out how far the disease has spread, and plan effective treatment for RCC.
PRIMARY OBJECTIVE:
I. To develop a blood test by monitoring the titer of IMP3 autoantibody and/or microRNA
(miRNA)/small non-coding RNA (snRNA) expression in patients' serum for the early detection of
RCC and its recurrence/metastasis.
OUTLINE: Serum samples are collected prior to treatment and analyzed for anti-IMP3
autoantibody titer via enzyme-linked immunosorbent assay (ELISA) and total RNA via
sequencing, microarray, and/or quantitative polymerase chain reaction (q-PCR). Previously
collected tissue samples are analyzed for IMP3 via immunohistochemistry (IHC).
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