Kidney Cancer Clinical Trial
Official title:
Immunotherapy for Patients With Renal Cell Carcinoma
RATIONALE: When irradiated donor lymphocytes are infused into the patient they may help the
patient's immune system kill tumor cells.
PURPOSE: This phase II trial is studying the side effects and how well giving irradiated
donor lymphocytes works in treating patients with metastatic kidney cancer.
OBJECTIVES:
- Determine the response rate in patients with metastatic renal cell carcinoma treated
with HLA-partially matched related donor lymphocytes.
- Determine the rate and kinetics of clinical/radiological response in patients treated
with this regimen.
- Determine the toxicity of this regimen in these patients.
- Determine the rates of graft-vs-host disease in patients treated with this regimen.
OUTLINE: Patients receive irradiated donor lymphocytes IV over 1 hour on day 0. Treatment
repeats every 8-16 weeks for up to 6 donor lymphocyte infusions in the absence of disease
progression or unacceptable toxicity.
Blood is collected periodically for research studies, including immunophenotypic analysis of
cells and assay for cytotoxic T-lymphocytes and natural killer-cell activity against target
cells.
After completion of study treatment, patients are followed for 60 days.
PROJECTED ACCRUAL: A total of 35 patients will be accrued for this study.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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