The Effect of Efudex Treatment on Photoaged Skin

Keratosis Clinical Trial

Official title:

The Effect of Efudex (5-fluorouracil) Treatment on Photoaged Skin

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00121511
• Other study ID #: Derm 549
• Secondary ID: 2005-0368
• Status: Completed
• Phase: N/A
• First received: July 13, 2005
• Last updated: May 26, 2015
• Start date: July 2005
• Est. completion date: July 2007

Study information

• Verified date: May 2015
• Source: University of Michigan
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

The researchers propose that skin improvements may be seen following a course of Efudex, (5-fluorouracil), a FDA-approved topical therapy (applied directly to the skin). These improvements could be the result of both a reduction of actinic keratoses (small red horny growths or flesh-colored wartlike growths caused by overexposure to ultraviolet radiation or the sun) and improvement of sun-damaged skin.

In addition, this research study is being done to determine if the expression of p53, a tumor suppressor gene (its activity stops the formation of tumors), is decreased following Efudex treatment. Mutations (abnormal changes) in the gene, called p53, are associated with a certain type of skin cancer. In addition, p53-mutated genes are known to exist in non-cancerous sun-damaged skin. Thus, the presence of p53 mutations may serve as a marker for both sun damage and an elevated risk of developing skin cancer.

Description:

Efudex (5-fluorouracil) has been used as topical chemotherapy for the treatment of actinic keratoses (AKs) since the 1950's. Through many years of use, Efudex has been deemed to be a safe and effective therapy. It requires, however, a high level of patient compliance and is known to cause a vigorous inflammatory reaction when actinic keratoses are treated. It has the distinct advantage of identifying precancerous skin lesions not apparent on clinical inspection or palpation. Following a course of Efudex to the face, patients have been noted to have fewer signs of dermatoheliosis.

The investigators propose to determine if Efudex is associated with improvement of aging skin in the setting of treating actinic keratoses. The researchers hope to demonstrate less p53 staining following Efudex treatment. It is proposed that the skin improvements seen following a course of Efudex are due to both reduction of actinic keratoses and impact on photoaging. The researchers propose to quantify the effects of Efudex therapy on the immunohistochemical staining properties of facial skin with respect to p53 and procollagen. The hypothesis is that Efudex therapy will decrease p53 immunostaining thus providing biochemical evidence to support this treatment in the reduction of actinic keratoses with concomitant improvement of aging skin.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 21
• Est. completion date: July 2007
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 50 Years and older

Eligibility

Inclusion Criteria:

• Age 50 or older of either gender.

• Patients must have actinic keratoses

• Patients must have clinical photoaging judged by rhytides, dyspigmentation, poikiloderma, lentigines, skin thinning, and/or telangiectases.

• Subjects must be in generally good health and willing to undergo skin biopsies from the face.

• Subjects must be willing and able to comply with the requirements of the protocol.

• You must live within a reasonable driving distance of Ann Arbor, Michigan, and/or be able to attend all of the scheduled appointments during the study.

Exclusion Criteria:

• Oral retinoid therapy (such as Accutane) within two months of study entry.

• Topical retinoid, imiquimod, or diclofenac therapy within 2 months of study entry.

• Prior laser re-surfacing, chemical peels for actinic keratoses or aging skin.

• Pregnant or nursing subjects.

• Non-compliant subjects.

• Subjects with a significant medical history or concurrent illness that the investigator feels is not safe for study participation.

• Prior systemic treatment with 5-fluorouracil.

• Known history of allergy to lidocaine (numbing medication), 5-fluoruracil, or any other known components of Efudex.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Keratosis
• Photo-aging

Intervention

Drug:
• Efudex (5-fluorouracil)

Locations

Country	Name	City	State
United States	University of Michigan Department of Dermatology	Ann Arbor	Michigan

Sponsors (2)

Lead Sponsor	Collaborator
University of Michigan	Valeant Pharmaceuticals International, Inc.

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Actinic Keratoses resolution and improvement in photoaging
Secondary	Changes in p53 immunostaining intensity will be used to assess response
Secondary	Collagen production will be evaluated by Western blotting, immunohistology, and RT-PCR