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Keratopathy clinical trials

View clinical trials related to Keratopathy.

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NCT ID: NCT04251143 Recruiting - Keratoconus Clinical Trials

Dresden Corneal Disease and Treatment Study

Start date: March 12, 2018
Phase:
Study type: Observational

The purpose of this study is long-term follow up of patients with corneal diseases to analyze the quality of surgical interventions and diagnosis. Corneal ectasia, especially keratoconus, is a corneal disease that leads to an irreversible loss of visual acuity while the cornea becomes steeper, thinner and irregular. For these patients, surgical intervention (e.g. corneal cross-linking) is performed, in case of disease progression. Overall, a long-term follow up is needed to evaluate an early disease progression as well as corneal stability after surgical intervention.

NCT ID: NCT04147390 Recruiting - Keratopathy Clinical Trials

Immunosuppression After Repeat Keratoplasty

Start date: November 2019
Phase: Phase 2/Phase 3
Study type: Interventional

Purpose: To compare the efficacy of topical 0.03% tacrolimus with systemic mycophenolate mofetil (MMF) in preventing corneal allograft rejection after repeat keratoplasty. Design: Prospective, randomized clinical trial Introduction: Repeat keratoplasty continues to be an important indication for corneal transplantation in many centers, and it accounts for up to 41% (varying from 6% to 41%) of all keraptoplasty cases performed. Methods: This study will enroll all patients who are candidate for repeat keratoplasty after a failed penetrating keratoplasty. Group 1 will receive MMF orally 1 g twice daily for the first 6 months and then 1 g daily for the next 6 months, and group 2 will receive topical 0.03 % tacrolimus 3 times a day for 12 months. All patients are treated with topical and oral corticosteroids postoperatively. The participants are observed closely for signs of graft rejection, and the rates of rejection-free graft survival are calculated and compared between the two groups at postoperative month 12

NCT ID: NCT03064984 Recruiting - Sjogren's Syndrome Clinical Trials

Blood Based Eyedrops From Different Sources in the Treatment of Severe Keratopathy

Start date: January 30, 2017
Phase: N/A
Study type: Interventional

Topical preparations (eye drops) derived from the blood have become a relatively common treatment for more advanced forms of keratopathy. The purpose of this study is to evaluate the effect of two blood components from donors (serum cord blood and serum from adult subject donor peripheral blood) in the treatment of severe keratopathies.

NCT ID: NCT01808378 Recruiting - Keratopathy Clinical Trials

Stem Cells Treatment for Bilateral Limbic Associated Keratopathy (HULPOFT)

HULPOFT
Start date: February 2013
Phase: Phase 2
Study type: Interventional

Evaluate the use of the autologous ASC for the treatment of bilateral limbic associated keratopathy