Keratoconus Clinical Trial
Official title:
Immunosuppression During Penetrating Keratoplasty, Using a Subconjunctival Implant Releasing Dexamethasone: Tolerance and Safety Pilot Study
Immune rejection episodes after penetrating keratoplasty occur in 30% of patients and
constitute one of the main factors reducing graft survival. They mainly occur during the
first 18 months. Prevention usually relies on a topical treatment with dexamethasone or
prednisolone for standard risk patients. Eye drops are instilled three times a day during at
least 3 months then tapered.
OZURDEX is an absorbable small implant that releases a total of 700 micrograms dexamethasone
during several months. It is indicated for intravitreal injection to treat macular edema.
The investigators hypothesized that this implant could be used after subconjunctival
injection during corneal graft, to prevent immune rejection and avoid repeated eyedrop
instillations.
n/a
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