| Eligibility |
Inclusion Criteria:
- Presence of central or inferior corneal steepening
- Axial topography consistent with keratoconus, post-surgical ectasia, or pellucid
marginal degeneration
- Presence of one or more findings associated with keratoconus or pellucid marginal
degeneration, such as:
- Fleischer ring
- Vogt's striae
- Decentered corneal apex
- Munson's sign
- Rizutti's sign
- Apical corneal scarring consistent with Bowman's breaks
- Scissoring of the retinoscopic reflex
- Crab-claw appearance on topography
- Steepest keratometry (Kmax) value > or = 47.20 D
- I-S keratometry difference > 1.5 D on the Orbscan map
- Posterior corneal elevation > 16 microns
- Thinnest corneal point < 485 microns
- Post LASIK/PRK stromal ablation depth < 300 microns or expected keratometry > 47.2 D,
or post-PRK/SMILE in keratoconus suspect eyes
- Bacterial or fungal corneal keratitis persistent and not responding despite > 2 weeks
of standard antimicrobial therapy or with rapid progression of corneal thinning, with
loss of > 25% corneal thickness
- Contact Lens Wearers Only:
- Removal of contact lenses for the required period of time prior to the screening
refraction:
Contact Lens Type Minimum Discontinuation Time Soft 1 Week Soft Extended Wear 2 Weeks Soft
Toric 3 Weeks Rigid Gas Permeable 2 Weeks per decade of wear
- Signed written informed consent
- Willingness and ability to comply with schedule for follow-up visits
Exclusion Criteria:
- Eyes classified as either normal or atypical normal on the severity grading scheme
- Corneal pachymetry at the screening exam that is < 400 microns at the thinnest point
in the eye(s) to be treated when the transepithelial (isotonic) riboflavin solution
alone will be used or < 300 microns when the hypotonic riboflavin will be used.
- Previous ocular condition (other than refractive error) in the eye(s) to be treated
that may predispose the eye for future complications, for example:
1. History of or active corneal disease (e.g., herpes simplex, herpes zoster
keratitis, recurrent erosion syndrome, acanthamoeba, etc.)
2. Clinically significant corneal scarring in the CXL treatment zone that is not
related to keratoconus or, in the investigator's opinion, will interfere with the
cross linking procedure
- Pregnancy (including plan to become pregnant) or lactation during the course of the
study
- A known sensitivity to study medications
- Patients with nystagmus or any other condition that would prevent a steady gaze during
the CXL treatment or other diagnostic tests
- Patients with a current condition that, in the physician's opinion, would interfere
with or prolong epithelial healing
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