Clinical Trials Logo

Clinical Trial Summary

This study is an exploratory trial evaluating the tear film break-up time after a single eye drop instillation of over-the-counter artificial tears. The primary hypothesis is that tear film break up time will be greater for test than control eye.


Clinical Trial Description

Subjects with varying degrees of dry eye syndrome were enrolled in a randomized, controlled, double masked, single site study. A new formulation of an artificial tear containing glycerin 1% as an active with polylysine-graft-polyethylene glycol as an excipient was compared against a leading commercial product with propylene glycol (0.3%) and polyethylene glycol (0.4%) as active ingredients with hydroxypropyl-guar as a gelling agent. The primary outcome was a comparison of tear film stability after eye drop instillation. ;


Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT00681265
Study type Interventional
Source Eyeon Therapeutics, Inc.
Contact
Status Completed
Phase N/A
Start date June 2008
Completion date August 2008

See also
  Status Clinical Trial Phase
Active, not recruiting NCT05618730 - Safety, Tolerability, Plug Retention and Preliminary Efficacy of Tacrolimus-loaded Punctal Plug in Patients With Moderate to Severe Dry Eye Disease - Cohort B Phase 1
Completed NCT02254265 - Phase 2/3 Dose-Ranging Study of the Safety and Efficacy of OTX-101 in the Treatment of Keratoconjunctivitis Sicca Phase 2/Phase 3
Completed NCT00883649 - Efficacy and Safety Study of Nutritional Supplements for Treatments of Dry Eye N/A
Completed NCT00717418 - Efficacy Study of Cyclosporine Ophthalmic Emulsion in Patients With Dry Eye Disease N/A
Completed NCT00128245 - Safety and Efficacy of Pimecrolimus Ophthalmic Suspension in Patients With Moderate to Severe Keratoconjunctivitis Sicca Phase 2
Enrolling by invitation NCT03436576 - Efficacy of Two Concentrations of Autologous Serum for the Treatment of Severe Dry Eye Phase 3
Completed NCT04147650 - Dose Ranging Study to Assess the Efficacy and Safety of Voclosporin Ophthalmic Solution in Subjects With Dry Eye Syndrome Phase 2/Phase 3
Completed NCT01733992 - A Safety, Tolerability and Pharmacokinetics Study of R932348 Eye Drops in Patients With Dry Eye Disease Phase 1
Completed NCT00987727 - Safety and Efficacy of Carboxymethylcellulose for Ocular Surface Integrity in Symptomatic Dry Eye Phase 4
Completed NCT00788229 - Efficacy and Safety Study of ATs in Patients With Dry Eye Syndrome Phase 2
Completed NCT00554879 - Acupuncture Treatment of Dry Eye N/A
Completed NCT00407043 - Multicenter, Randomized, Controlled Study of the Effect of Lotemax on Initiation of Dry Eye Treatment With Restasis Phase 4
Completed NCT00001731 - Treatment of Dry Eye Syndrome With Cyclosporin A Eye Drops Phase 2
Recruiting NCT03953703 - Levocarnitine for Dry Eye in Sjogren's Syndrome Phase 2
Withdrawn NCT03398018 - Repository Corticotropin Injection in Keratoconjunctivitis Sicca Phase 4
Recruiting NCT02066896 - Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome Phase 3
Completed NCT02139033 - A Phase 4 Study Investigating the Efficacy of Retaineā„¢ in Managing Signs and Symptoms Associated With Dry Eye Syndrome Phase 4
Terminated NCT01213342 - Omega-3 Fatty Acid Supplements and Dry Eye N/A
Completed NCT00201955 - Study of Rebamipide Eye Drops to Treat Dry Eye Phase 3
Completed NCT00201981 - Study of Rebamipide Eye Drops to Treat Dry Eye Phase 3