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Clinical Precise Diagnosis and Treatment in the Kawasaki Disease

Kawasaki Disease Clinical Trial

Official title:
Clinical Precise Diagnosis and Treatment of Personalized Z-score Evaluation Combined With Genomic Analysis in the Repair of Coronary Artery Injury in Kawasaki Disease

Clinical Trial Summary

The purpose of this project is to explore the differential gene expression profile of Kawasaki disease, and will explore the diagnosis and treatment targets related to coronary artery injury or kawasaki disease susceptibility, vascular damage, IVIG (intravenous immunoglobulin) treatment resistance, incomplete Kawasaki disease, etc.

Clinical Trial Description

After being informed about the study and potential risks, all patients giving written informed consent will acquire blood samples with complete clinical data and prognostic information. Using clinicopathology, molecular biology, gene diagnostics and other techniques to verify the expression differences of target genes and proteins and analyze their expression levels; To analyze the role of target genes and proteins in the occurrence and development of Kawasaki disease and their correlation with the risk of coronary artery injury. In vitro and in vivo KD (Kawasaki Disease) model was used to investigate the role of target genes in Kawasaki disease by gene interference and various molecular biological techniques. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05347901
Study type Observational
Source Affiliated Hospital of Nantong University
Contact Jianmei Zhao, PhD.
Phone 051385052399
Email zjmheart@163.com
Status Recruiting
Phase
Start date August 1, 2021
Completion date July 31, 2024
View Details
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