Kallmann Syndrome Clinical Trial
Official title:
The Effects of 7 Days of Exogenous Pulsatile GnRH Treatment on the Pituitary-Gonadal Axis in Hypogonadotropic Hypogonadal Subjects
Verified date | June 2022 |
Source | Massachusetts General Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Men with Idiopathic Hypogonadotropic Hypogonadism (IHH) lack a hormone called gonadotropin releasing hormone (GnRH). This hormone is important for starting puberty, maintaining testosterone levels, and fertility. The purpose of this study is to research the effects of treating IHH men with GnRH for 7 days.
Status | Completed |
Enrollment | 27 |
Est. completion date | November 17, 2009 |
Est. primary completion date | November 17, 2009 |
Accepts healthy volunteers | No |
Gender | Male |
Age group | 18 Years to 65 Years |
Eligibility | Inclusion Criteria: - Diagnosis of idiopathic hypogonadotropic hypogonadism (IHH) or Kallmann syndrome (KS)Adult male 18-65 years of age - Serum testosterone <100 ng/dL Exclusion Criteria: - No specific exclusion criteria |
Country | Name | City | State |
---|---|---|---|
United States | Massachusetts General Hospital | Boston | Massachusetts |
Lead Sponsor | Collaborator |
---|---|
Massachusetts General Hospital |
United States,
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* Note: There are 18 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | testosterone | daily for 7 days | ||
Primary | LH | frequent sampling for 2 hours | ||
Primary | FSH | frequent sampling for 2 hours | ||
Primary | Inhibin B | daily for 7 days | ||
Primary | free alpha subunit | daily for 7 days |
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