Joint Discomfort Clinical Trial
Official title:
Randomized Double-blind, Placebo Controlled Study to Asses the Efficacy and Safety of a Native Collagen Food Supplement on Joint Function, Ultrasound Evolution and Quality of Life of Adults With Moderate Knee Pain
This study evaluates the effects of 40 mg of b-2Cool, a food supplement rich in native type-II collagen, on healthy adults with joint discomfort. Half of the participants will receive the b-2Cool containing supplement while the other half will receive a placebo pill.
Previous studies had shown the efficacy of the intake of native collagen to relieve pain in
healthy patients with joint discomfort.
Native collagen is detected in the gut's Peyer's patches and, thanks to a mechanism known as
oral tolerisation, reduces the autoimmune attack to joints' collagen improving joint function
and pain.
Oral tolerance consists of two phases of immune response: the maintenance of homeostasis and
the suppression of immune responses mediated by Ag-specific regulatory T cells. T-cells
detect the epitopes of type-II collagen in the gut and suppress the immune response against
bodily type-II collagen. Then, these regulatory T cells generated in the gut are presumed to
migrate to a local microenvironment where a protein analogous to the orally dosed antigen
resides, in this case type-II collagen. Upon reactivation in a new microenvironment,
regulatory cells will suppress ongoing inflammation.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04955353 -
Efficacy of a Hydrolyzed Chicken Collagen Type II in Alleviating Joint Discomfort
|
N/A |