Clinical Trials Logo
  1. Home
  2. Jaundice
  3. NCT02224586
  4. Details
NCT02224586 Clinical Trial

Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment.

Jaundice Clinical Trial

Official title:
Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment.

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT02224586
Other study ID # HNU_AH_jaundice fMRI
Secondary ID
Status Recruiting
Phase N/A
First received August 20, 2014
Last updated August 21, 2014
Start date August 2014
Est. completion date July 2015

Study information
Verified date August 2014
Source Hangzhou Normal University
Contact Xiao-Bao Xue
Email baobao871015@163.com
Is FDA regulated No
Health authority China: Ethics Committee
Study type Observational

Clinical Trial Summary

It is just an observation study. The investigates want to explore the signal changes of resting state functional Magnetic resonance Imaging (fMRI) after light treatment in jaundice infants. Signal changes contain blood oxygenation level dependent (BOLD) and arterial spin labeling (ASL).Indicator of BOLD is amplitude of low-frequency fluctuation（ALFF).Indicator of ASL is cerebral blood flow (CBF).

The investigates assume that the children with jaundice after light therapy, ALFF and CBF will change. Focus on the globus pallidus and subthalamic nuclei. The two brain regions were proved to be abnormal in MRI T1, T2 structure signal in kernicterus.

Doctors observe the status of infants aside.Using monitoring probe can see clearly.

Description:

resting state fMRI scan light therapy the second time resting state fMRI scan

Recruitment information / eligibility
Status Recruiting
Enrollment 20
Est. completion date July 2015
Est. primary completion date March 2015
Accepts healthy volunteers No
Gender Both
Age group N/A to 28 Days
Eligibility Inclusion Criteria:

- hyperbilirubinemia

Exclusion Criteria:

- asphyxia

- cerebral dysgenesis

Study Design

Observational Model: Case-Crossover, Time Perspective: Prospective

Related Conditions & MeSH terms

Intervention

Device:
• light treatment
clinical routine treatment according to the doctor's advice

Locations
Country Name City State
China Center for Cognition and Brain Disorders Hangzhou Zhejiang

Sponsors (1)
Lead Sponsor Collaborator
Hangzhou Normal University

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary amplitude of low-frequency fluctuation change before and after light treatment It is indicator of blood oxygenation level dependent. before and after light treatment Yes
Secondary cerebral blood flow change before after light treatment It is indicator of arterial spin labeling. before and after light treatment Yes
See also
  Status Clinical Trial Phase
Completed NCT00383318 - Demographic, Metabolic, and Genomic Description of Neonates With Severe Hyperbilirubinemia N/A
Completed NCT00360204 - Improving Health Outcomes for New Mothers and Babies Phase 3
Withdrawn NCT04021927 - Development of a Neonatal Jaundice Treatment Accelerator by Redirection of Unused Light During Phototherapy N/A
Completed NCT00966719 - Breastfeeding Support Intervention in Jaundiced Infants N/A
Completed NCT02033096 - Observational Follow-up of Participants From Clinical Trial 64,185-202 (NCT00850993)
Terminated NCT01514058 - A Prospective, Randomized Study Evaluating the Effect of Biliary Stenting on EAU-FNA in Patients With Suspected Malignant Biliary Obstruction N/A
Active, not recruiting NCT01683708 - Effectiveness Of Symbiotic Therapy In Jaundiced Patients N/A
Completed NCT01203410 - Prediction of Jaundice in Term Infants
Not yet recruiting NCT06232174 - Value of Transcutaneous Bilirubin Devices
Completed NCT01356030 - Endoscopic Ultrasound Versus Endoscopic Retrograde Cholangiopancreatography (ERCP) Tissue Sampling for the Diagnosis of Suspected Pancreatico-Biliary Cancer N/A
Not yet recruiting NCT06276738 - The LINFU® U.S. Registry in Patients With Clinical Signs and/or Symptoms of Disease
Completed NCT02787512 - Preoperative Biliary Drainage With Metal Versus Plastic Stents in Periampullary Cancer N/A
Completed NCT02991339 - The Effects of Dexamethasone Administration on Jaundice Following Liver Resection Phase 2/Phase 3
Withdrawn NCT00240123 - Effect of Benadryl Sedation During ERCP or EUS Phase 1
Completed NCT02926131 - A Study to Evaluate a New Jaundice Stick Test
Completed NCT01499537 - Prospective Randomized Study of PTC and EUS-guided Drainage of the Bile Duct N/A
Active, not recruiting NCT02376907 - Biliary Drainage in Patients With Duodenal Metal Stent N/A
Terminated NCT01887041 - Quality of Life After Biliodigestive Anastomosis (BDA) or Stents to Treat Biliary Obstruction in Pancreas Cancer Phase 4
Recruiting NCT06173947 - SSM Predicts Outcomes of CLD Inpatients With Acute Liver Injury
Active, not recruiting NCT04271176 - Jaundice as Initial Presentation of Liver Hydatidosis (ICTEHIDA)