Japanese Encephalitis Vaccine Clinical Trial
Official title:
Characterisation of Cellular and Humoral Immune Responses Following the First Booster Immunisation With the Inactivated, Purified Japanese Encephalitis Vaccine IXIARO® in Elderly Compared to Young Individuals.
The aim of this study is to investigate the immune responses following a booster immunisation with the Japanese Encephalitis vaccine in elderly subjects (above 60 years of age) in comparison to a young study group.
The condition under investigation is the naturally aging immune system. The aim of this study
is to investigate the immune responses following a booster immunisation with the Japanese
Encephalitis vaccine in elderly subjects (above 60 years of age) in comparison to a young
study group.Testing the difference of the JEV-antibody titre increase between young and
elderly adults between visit 1 (before booster vaccination) and up to visit 4 (6 months after
booster vaccination).
Testing cellular immunity (cytokine production after JEV as well as TBE stimulation) on visit
1, 2 (one week after booster immunisation) and 3 between both age groups.
Testing of surface markers of different T and B cell subsets before and after JE-booster
vaccination (on visit 1-3) in comparison between both age groups.
Testing TBE-antibody titres before and after JE-booster vaccination (on visit 1-4) in both
age groups.
Testing CMV serology at visit 1 in both age groups.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01656200 -
A Prospective, Open Label Study of Human T Cell Responses to Live Attenuated Japanese Encephalitis Vaccine SA14-14-2
|
Phase 4 |