A Cohort Study of Environmental Endocrine Disrupting Chemicals and Female Reproductive Health

IVF Clinical Trial

— PKU-ERC  

Official title:

Adverse Effects and Mechanism of Environmental Endocrine Disrupting Chemicals on Female Reproductive health--the Peking University and Environment Reproductive Health Cohort

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05373290
• Other study ID #: PKUPHIVF001
• Status: Recruiting
• Start date: January 1, 2018
• Est. completion date: December 2022

Study information

• Verified date: May 2022
• Source: Peking University People's Hospital
• Contact: Huan Shen, Doctor
• Phone: 86010-88324436
• Email: rmivf[@]sina.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Infertility is a disease that seriously affects the physical and mental health of women of childbearing age. The incidence of infertility has been increasing in recent years. Studies have shown that the occurrence of infertility may be related to environmental endocrine disrupting substances. This project was designed to establish a cohort study on environmental endocrine disrupting substances and in vitro fertilization (IVF) treatment, collect blood, urine, semen, follicular fluid, granulosa cells, chorionic decidua biological specimens, and then follow up on the pregnancy outcomes. The concentration of disrupting substances was detected and then found the associations between environmental endocrine disrupting substances and female reproductive health.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 2000
• Est. completion date: December 2022
• Est. primary completion date: December 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

Clinical diagnosis of infertile patients undergoing IVF treatment

Exclusion Criteria:

Donor egg transplants excluded

Related Conditions & MeSH terms

• IVF

Intervention

Other:
• there is no intervention in the study
there is no intervention in the study

Locations

Country	Name	City	State
China	Peking University People's Hospital	Beijing	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Peking University People's Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of eggs retrieved	the number of eggs retrieved in the process of in vitro fertilization (IVF)	immediately after the eggs retrieved
Primary	the number of available embryos	the number of available embryos in the process of IVF	1 week after the eggs retrieved
Primary	the clinical pregnancy rate	the clinical pregnancy rate in the process of IVF	4 weeks after the embryos transfer
Primary	the miscarriage rate	the miscarriage rate in the process of IVF	7 months after embryos transfer
Primary	the live birth rate	the live birth rate in the process of IVF	40 weeks after embryos transfer