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Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine (Second Sub-Project)

Itch Clinical Trial

Official title:
Effect of Intradermal Morphine Application on Histaminergic and Non-histaminergic Itch and Related TRPV1 and Antihistamine Treatments (2nd Sub-project)

Clinical Trial Summary

The aim of our 2nd sub-project is to clarify if the capsaicin receptor TRPV1 is implicated in the mechanism of morphine-induced mast cell degranulation. Moreover, we also aim to clarify if the mechanism of opioid-induced itch relay on the histaminergic pathway by using the antihistamine (diphenhydramine) to suppress the release of histamine from peripheral mast cells.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04700007
Study type Interventional
Source Aalborg University
Contact
Status Completed
Phase N/A
Start date January 18, 2021
Completion date December 31, 2021
View Details
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