Itch Clinical Trial
Official title:
A Mechanistic Study on Morphine-induced Orthogonal Neural Plasticity for Itch and Pain Processing in Humans (a Relation of Morphine-induced Itch and Pain Processing)
In This experiment, the investigators would like to test the two following hypotheses
regarding the mechanisms by which opioids cause itch:
1. Opioids cause itch by a spinal disinhibition mechanism (central nervous system (CNS)
effect).
2. Opioids cause itch through a mast cell-destabilizing effect leading to release of
histamine and tryptase in the skin where itch is evoked (peripheral mechanism).
Intrathecal and orally administered opioids are heavily used for the treatment of several
acute pain conditions. However, while opioids are effective analgesics for acute pain, they
are well-known to frequently cause itch (pruritus) as a side effect according with the two
hypotheses stated above. So far, these two hypotheses have never been tested in humans.The
present study describes a proposed study design for the purpose of confirming these two
hypotheses in parallel in human subjects.
Primary endpoints of the study:
To evaluate changes itch and pain perception, and superficial perfusion after each itch
provocations.
Secondary endpoints of the study:
To evaluate the existence of a correlation between itch sensitization and analgesic efficacy.
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