Clinical Trials Logo
  1. Home
  2. ITCH
  3. NCT03943407

Characterization of the Toll-like Receptor 7-agonist Imiquimod 3.75% as a New Surrogate Model of Itch

Itch Clinical Trial

Official title:
Characterization of the Toll-like Receptor 7-agonist Imiquimod 3.75% as a New Surrogate Model of Itch

Clinical Trial Summary

The aim of this research project is to design a new model of human itch by application of Zyclara cream. Further, the aim is to characterize the model and to verify if the mechanism of action of imiquimod follows the histaminergic or non-histaminergic pathway by using the anti-histamine drug doxepin. The last goal is to evaluate the interaction between the activation of TLR7 receptor and the activation of TRPA1 and TRPM8 receptors, which are two of the most important receptors involved in the transduction of noxious stimuli, and to evaluate to which extent these three channel populations functionally overlap.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03943407
Study type Interventional
Source Aalborg University
Contact
Status Withdrawn
Phase N/A
Start date November 2019
Completion date June 2022
View Details
See also
  Status Clinical Trial Phase
Completed NCT01683552 - Aprepitant in the Management of Biological Therapies-related Severe Pruritus Phase 2
Completed NCT02075632 - Study to Evaluate Product Duration of Use Experience With Alclometasone Dipropionate Cream Phase 2
Completed NCT04515056 - Characterization of New Human Models of Non-histaminergic Itch N/A
Completed NCT04076865 - Evaluation of the Effect Induced by Repeated Administration of Topical Local Anaesthetic (EMLA) on Itch N/A
Completed NCT04588532 - Characterization of BAM8-22 as a New Surrogate Model of Non-histaminergic Itch N/A
Enrolling by invitation NCT05195177 - Testing Protocol to Efficiently Induce Itch N/A
Completed NCT04858360 - Inhibition of Non-histaminergic Pruritus Applied Using 3 Different Pruritogens N/A
Completed NCT04635254 - The Effect of Halophyte-based Cream on Pain and Itch N/A
Not yet recruiting NCT06201715 - Efficacy and Safety of Tofacitinib in Patients With Prurigo Nodularis N/A
Completed NCT06036589 - Characterization of Bovine Adrenal Medulla as a Model of Non-histaminergic Itch N/A
Completed NCT04554888 - Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor N/A
Completed NCT04387851 - Learning Mechanisms for Placebo and Nocebo Studies on Somatosensory Sensations: a Systematic Review and Meta-analysis.
Completed NCT03928223 - The Color of Itch; Itch Modification by Color Viewing
Not yet recruiting NCT06245564 - Effect of Ketamine, Amitriptyline and Their Combination on Histaminergic and Non-histaminergic Itch N/A
Completed NCT03576053 - A Mechanistic Evaluation of the Interactions Between Thermoceptive and Pruriceptive Sensory Processing N/A
Completed NCT04700007 - Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine (Second Sub-Project) N/A
Terminated NCT02828787 - Central Mechanisms of Chronic Pruritus: Functional and Structural Brain Imaging. N/A
Completed NCT04115462 - A Relation of Morphine-induced Itch and Pain Processing N/A
Not yet recruiting NCT04197440 - Characterization of Bovine Adrenal Medulla (BAM8-22) as a New Surrogate Model of Non-histaminergic Itch N/A
Completed NCT05249387 - Characterization of Bovine Adrenal Medulla as a New Surrogate Model of Non-histaminergic Itch N/A