Itch Clinical Trial
— PRURIMOfficial title:
Central Mechanisms of Chronic Pruritus: Functional and Structural Brain Imaging.
Verified date | November 2020 |
Source | University Hospital, Brest |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The main objective of this study is to identify by functional and structural MRI which are the brain areas activated in various pruritic situations to deduct a model describing the different causes of pruritus. The investigators are going to compare two chronic pruritus conditions (histaminergic urticaria and non histaminergic: psoriasis) to a healthy control group. The secondary objective of this study is to specify a classification index from the physiological results obtained by brain imaging to differentiate multiple types of pruritus.
Status | Terminated |
Enrollment | 31 |
Est. completion date | May 31, 2018 |
Est. primary completion date | May 31, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Or patient affected by psoriasis presenting a pruritus of more than 6 weeks - Or patient affected by urticaria presenting a pruritus of more than 6 weeks - Or subject without dermatosis and not presenting chronic pruritus. - Major - Able to provide written informed consent - Affiliated to the Social Security Exclusion Criteria: 1. In connection with the award of an MRI namely: - The presence of implanted medical equipment susceptible to the magnetic field of MRI, - Claustrophobia - Medication, treatment and / or substances that could alter or modify brain function - Pregnancy 2. In connection with the mode of presentation of stimuli (video): - An uncorrected visual disorder not allowing to view videos 3. In connection with the administrative regulations: - Persons under 18 - Major Persons subject to legal protection (backup justice, trusteeship, guardianship), persons deprived of liberty. If no pruritus is induced during the first session, it will be a criterion for non inclusion for the second session. |
Country | Name | City | State |
---|---|---|---|
France | CHRU de Brest | Brest | |
France | Laurent MISERY | Brest |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Brest |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | brain areas activated during a mentally induced pruritus in 3 different populations | The primary endpoint is to highlight fMRI brain areas activated during a mentally induced pruritus in 3 different populations: healthy subjects (no pre-existing pruritus), patients with chronic urticaria (pruritus related to histaminergic pathway), and psoriasis patients (activation pathway pruritus probably PAR2-ergic but to be confirmed by the study). | 1 year | |
Secondary | index, form the combination the better able to explain the membership of an individual (individual analysis) to a pathological community or not. | The secondary outcome is to verify that data collected, once grouped and established in index, form the combination the better able to explain the membership of an individual (individual analysis) to a pathological community or not. | 1 year |
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