Biomarkers for Intestinal Permeability in Patients With Constipation

Status Completed

Clinical Trial Summary

Our overall objective with this study is firstly to provide a comprehensive assessment of intestinal permeability, mucosal barrier function using existing biomarkers and secondly to explore novel biomarkers for measuring intestinal permeability in patients with constipation predominant Irritable Bowel Syndrome (IBS-C).

Clinical Trial Description

In order to determine the differences in permeability in IBS-C in comparison with healthy volunteers, the following will be determined: differences in in vivo small intestinal and colonic permeability, differences in small intestinal and colonic mucosal barrier function, differences in effects of fecal supernatants on barrier function of T84 monolayers, and differences in novel biomarkers for intestinal permeability ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02246647
Study type	Observational
Source	Mayo Clinic
Contact
Status	Completed
Phase
Start date	September 2014
Completion date	December 8, 2016

View Details

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