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Residual Dental Pulp Tissue and Cord Blood Stem Cells

Irreversible Pulpitis Clinical Trial

Official title:
Effect of Residual Dental Pulp Tissue and Cord Blood Stem Cells on Regeneration of Dental

Clinical Trial Summary

The experiments outlined in this proposal are designed to test the hypothesis that the in vivo injection of cord blood stem cells (InvitRx®) into the root canal system will facilitate teeth initially diagnosed with irreversible pulpitis, to form normal healthy pulpal tissue.

Clinical Trial Description

Patients will be recruited from the various dental clinics at UCSF (student clinic, Advanced Education in General Dentistry clinic, post-graduate endodontics clinic, etc) that meet the inclusion and exclusion criteria. Patients in the control group will have root canal therapy initiated; instrumentation and cleaning up to 4mm from the radiographic apex. Bleeding will be induced and blood clot formed 3mm from the CEJ. MTA followed by glass ionomer and composite will be placed over the clot. Patients in the experimental group will have root canal therapy initiatied; instrumentation and cleaning up to 4mm from the radiographic apex. Bleeding will be induced and blood clot formed 3mm from the CEJ. 1 cc (30 million cord blood stem cells) will then be injected into the clot formation. MTA followed by glass ionomer and composite will be placed over the clot. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04040127
Study type Interventional
Source University of California, San Francisco
Contact
Status Withdrawn
Phase Phase 2
Start date September 1, 2019
Completion date February 28, 2020
View Details
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