Irreversible Pulpitis Clinical Trial
Official title:
Premedication Efficacy of Ketorolac Infiltration on Post Endodontic Pain
Objective: The aim of this study is to evaluate premedication with ketorolac infiltration on
post endodontic pain in patients with symptomatic irreversible pulpitis.
Design: Randomized double blind clinical trial
Setting and conduct: Sixty adult volunteers with including criteria will be divided into two
groups (n=30) based on random table. All patients will receive standard inferior alveolar
nerve block of 2% lidocaine with 1:800000 epinephrine and supplemental buccal infiltration of
0.9 mL 2% lidocaine with 1:800000 epinephrine. After five minutes one group will receive
supplemental buccal infiltration of 30 mg/mL of Ketorolac Tromethamine and the control group
will receive buccal infiltration of normal saline. Endodontic access preparation will
initiate after 15 minutes of initial IANB with two negative responses to the electric pulp
test. The pain level will be recorded immediately and at the 2,4,6 and 24 hours following the
treatment using Heft- Parker Visual Analog Scale (HP- VAS). Data will be evaluated using
Repeated measured test (if possible) and otherwise non-parametric tests such as rival
Friedman and X2 test. Participants including major eligibility criteria: all patients age
ranged 18-65 with symptomatic irreversible pulpitis (HP VAS ≥54) and without pain on
percussion on a mandibular molar tooth who need root canal treatment and are without systemic
diseases; nonsmoking; non pregnant, non breast feeding without any medicine consumption or
analgesic and sedation
Intervention: Ketorolac infiltration
Main outcome measures: Pain level at immediately after the treatment, 2, 4, 6 and 24 hours
following the root canal treatment using HP VAS.
Objective: The aim of this study is to evaluate premedication with ketorolac infiltration on
post endodontic pain in patients with symptomatic irreversible pulpitis.
Design: Randomized double blind clinical trial
Setting and conduct: Sixty adult volunteers with including criteria will be divided into two
groups (n=30) based on random table. All patients will receive standard inferior alveolar
nerve block of 2% lidocaine with 1:800000 epinephrine and supplemental buccal infiltration of
0.9 mL 2% lidocaine with 1:800000 epinephrine. After five minutes one group will receive
supplemental buccal infiltration of 30 mg/mL of Ketorolac Tromethamine and the control group
will receive buccal infiltration of normal saline. Endodontic access preparation will
initiate after 15 minutes of initial IANB with two negative responses to the electric pulp
test. Endodontic treatment of all the patients will be performed in a single visit, using
crown down method and with rotary instrumentation till master apical file size# 30.06. The
pain level will be recorded immediately and at the 2,4,6 and 24 hours following the treatment
using Heft- Parker Visual Analog Scale (HP- VAS). Data will be evaluated using Repeated
measured test (if possible) and otherwise non-parametric tests such as rival Friedman and X2
test. Participants including major eligibility criteria: all patients age ranged 18-65 with
symptomatic irreversible pulpitis (HP VAS ≥54) and without pain on percussion on a mandibular
molar tooth who need root canal treatment and are without systemic diseases; nonsmoking; non
pregnant, non breast feeding without any medicine consumption or analgesic and sedation
Intervention: Ketorolac infiltration
Main outcome measures: The pain level immediately and at the 2, 4, 6 and 24 hours following
the treatment using HP- VAS
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