Fetal Parenchymatic Evaluation (Liver, Spleen) Using T2* Sequences

Status Not yet recruiting

Clinical Trial Summary

The purpose of this study is to prospectively evaluated the T2* values of normal feti.A standardized scale of T2* values for fetal and neonatal iron organ overload have yet to be reported or devised.

Clinical Trial Description

The purpose of this study is to prospectively evaluate the T2* values of normal feti. This study will be offered to mothers undergoing fetal MRI for any indication. Subjects will be required to sign an informed consent from. The addition of T2* sequences will add 2-4 minutes to the whole scan, not exposing the mother or the fetus to ionizing radiation or the administration of contrast material. A standardized scale has been created and multi-center studies have been conducted using different vendor scanners in order to verify the consistency of these scale. T2 and T2* sequences have been addressed anecdotally in the literature as non invasive options for the evaluation fetal iron deposition . However, a standardized scale of T2* values for fetal and neonatal iron organ overload have yet to be reported or devised. ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Iron Overload

Clinical Trial Details

NCT number	NCT01121094
Study type	Observational
Source	Sheba Medical Center
Contact	Orly Goitein, MD
Phone	+972 3 5302530
Email	orly.goitein@sheba.health.gov.il
Status	Not yet recruiting
Phase	N/A
Start date	June 2010
Completion date	June 2012

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04423237` - Risk Factors and Measures to Prevent Liver and Pancreas Complications in Pediatric Patients After HSCT
Completed	`NCT04614779` - Long-term Clinical Study of CN128 in Thalassemia Patients	Phase 2
Withdrawn	`NCT03800446` - Validation of a Point-of-care Device Measuring Ferritin With Capillary Blood	N/A
Not yet recruiting	`NCT02833493` - Study of MRI Monitoring in Patients With Aplastic Anemia and Low or Int-1 Risk of MDS Complicated With Iron Overload	N/A
Completed	`NCT02164253` - Focal Accumulation of Iron in Cerebral Regions in Early ALS (Amyotrophic Lateral Sclerosis) Patients	Phase 2
Completed	`NCT00901199` - Combined Chelation Therapy in Patients With Transfusion Dependent Thalassemia and Iron Overload	Phase 2
Completed	`NCT00512226` - Iron Overload Assesment in Sickle Cell Anemia and Sickle Cell Thalassemia	N/A
Recruiting	`NCT00378469` - Study of the Effects of Muscular Activity on Iron Metabolism	N/A
Completed	`NCT00117507` - Study for the Treatment of Transfusional Iron Overload in Myelodysplastic Patients	Phase 4
Completed	`NCT00138684` - Cytochrome P450 2E1 and Iron Overload	Phase 2
Completed	`NCT03990181` - Inhibiting Dietary Iron Absorption in Subjects With Hereditary Hemochromatosis by a Natural Polyphenol Supplement	N/A
Terminated	`NCT02274233` - Safety and Pharmacokinetic Study of Escalating Doses of SP-420, an Iron Chelator, in Patients With β-Thalassemia	Phase 1
Active, not recruiting	`NCT01443195` - Iron Metabolism in Small Pre Term Newborns	N/A
Completed	`NCT01546415` - Safety and Efficacy of Desferasirox in Chinese Patients With Iron Overload and Aplastic Anemia	Phase 4
Completed	`NCT01572818` - Effects of Phlebotomy on Insulin Sensitivity in Insulin Resistance-associated Hepatic Iron Overload Patients	N/A
Not yet recruiting	`NCT00980421` - Safety of Various Mode of Delivery of Iron Supplement on Iron Toxicity Markers in Preschool Children	Phase 3
Completed	`NCT01047098` - Effects of Taking Prenatal Vitamin-mineral Supplements During Lactation on Iron Status and Markers of Oxidation	N/A
Recruiting	`NCT05294471` - Fully Automated High-Throughput Quantitative MRI of the Liver
Completed	`NCT03591575` - Safety and Efficacy of Early Treatment With Deferiprone in Infants and Young Children	Phase 4
Active, not recruiting	`NCT00907283` - Ferrochelating Treatment in Patients Affected by Neurodegeneration With Brain Iron Accumulation (NBIA)	Phase 2