Iron Absorption Clinical Trial
Official title:
Metabolic Adaptation to Plant-based Diets in Asian Populations
Verified date | July 2014 |
Source | Cornell University |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Institutional Review Board |
Study type | Observational |
The two specific aims of this study are: 1) to assess the impact of a genetic variant on iron status; 2) to assess the impact of a genetic variant on non-heme absorption among Asian women. The investigators hypothesize that the genetic variant could enhance iron status and iron absorption in Asian women.
Status | Completed |
Enrollment | 57 |
Est. completion date | May 2014 |
Est. primary completion date | April 2013 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 35 Years |
Eligibility |
Inclusion Criteria: - non-pregnant and between the ages of 18~35 y - East Asian descent with both maternal and paternal grandparents from East Asia, including China, Japan, South Korea, Vietnam, Thailand, Malaysia and Singapore Exclusion Criteria: - taking or planing to take any vitamin or mineral supplements during the study period - pre-existing medical problems that might impact inflammation or Fe status, including malabsorption, blood disorders, ulcers, joint diseases and asthma - taking any prescribed medications known to affect iron homeostasis |
Observational Model: Case-Only, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
United States | Human Metabolic Research Unit, Cornell University | Ithaca | New York |
Lead Sponsor | Collaborator |
---|---|
Cornell University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Genotype at SNP rs9366637 | At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining genotype. | 2 weeks after the participant's visit to the laboratory | No |
Primary | Hemoglobin | At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of hemoglobin. | Up to 2 days after the participant's visit to the laboratory | No |
Primary | Serum Ferritin | At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of serum ferritin. | Up to 6 months after the participant's visit to the laboratory | No |
Primary | Serum transferrin receptor | At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of serum transferrin receptor. | Up to 6 months after the participant's visit to the laboratory | No |
Primary | Non-heme Iron absorption in women with 2 HFE genotypes | Women donated a blood sample for genotyping. Women with particular HFE genotypes were invited to return for an absorption study. Two weeks after women consume the iron tracer, a blood sample was obtained to measure the amount of iron absorbed. | one month for screening with genotype then 2 weeks for iron absorption study | No |
Secondary | Folate | At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of folate. | Up to 6 months after the participant's visit to the laboratory | No |
Secondary | Vitamin B-12 | At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of vitamin B-12. | Up to 6 months after the participant's visit to the laboratory | No |
Secondary | C-reactive protein | At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of C-reactive protein. | Up to 6 months after the participant's visit to the laboratory | No |
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