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NCT ID: NCT02943057 Active, not recruiting - Clinical trials for Cytomegalovirus Infections

Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis

Start date: October 2016
Phase: Phase 4
Study type: Interventional

25 patients who are diagnosed with Cytomegalovirus (CMV) anterior segment infection, either uveitis or endotheliitis, will be started on 2% guttae ganciclovir, 1 drop 5 times a day for 6 weeks. Following 6 weeks of continuous application of 2% guttae ganciclovir, patient will be reviewed at the clinic within 3 hours following the last application of topical ganciclovir and clinical features will be documented for activity assessment. An aqueous sample 0.2ml is drawn. 0.1ml will be sent for RT-PCR for CMV viral load and another 0.1ml will be sent for ganciclovir drug level by HPLC method.