Invitro Fertilization Clinical Trial
Official title:
Value of Cabergoline and Low Dose Aspirin in Poor Responders Undergoing ICSI-ET Using Microdose GnRH Agonist Flare-Up-Protocol
Ovarian stimulation will be done using the Microdose flare-up regimen. The patient will
receive diluted doses of the GnRH agonist leuprolide acetate 40 µg, given subcutaneously
twice daily. Two days later, stimulation will be initiated by intramuscular (IM) injections
of HMG (Merional, IBSA, Germany) in a dose of 300 IU/day.
Follicular monitoring began from the ninth day of the cycle by serial vaginal ultrasonography
and measurement of serum E2 levels. IM injections of 10000 IU HCG (Choriomon; IBSA, Germany)
will be injected when at least 2 follicles 18 mm were observed on ultrasonography.
Oocytes willbe retrieved 36 hours after hCG injection using a 17-gauge aspiration needle
under transvaginal ultrasound guidance. The pelvis is evaluated with ultrasound to ensure
that there is no internal bleeding.
After fertilization was confirmed when two polar bodies and two pronuclear were observed
18-20 hours after insemination, one to three grade A embryos were transferred at day 3
fertilization.
The luteal phase support will be initiated from the day of oocyte retrieval for all patients
with (Cyclogest 400 mg, Actavis pharmaceutical, UK) vaginal suppositories per day till the
day of serum pregnancy test was done.
Ovarian stimulation was done using the Microdose flare-up regimen. The patient received
diluted doses of the GnRH agonist leuprolide acetate 40 µg, given subcutaneously twice daily.
Two days later, stimulation is initiated by intramuscular (IM) injections of HMG (Merional,
IBSA, Germany) in a dose of 300 IU/day.
Follicular monitoring began from the ninth day of the cycle by serial vaginal ultrasonography
and measurement of serum E2 levels. IM injections of 10000 IU HCG (Choriomon; IBSA, Germany)
were injected when at least 2 follicles 18 mm were observed on ultrasonography.
Oocytes were retrieved 36 hours after hCG injection using a 17-gauge aspiration needle under
transvaginal ultrasound guidance. The pelvis is evaluated with ultrasound to ensure that
there is no internal bleeding.
After fertilization was confirmed when two polar bodies and two pronuclear were observed
18-20 hours after insemination, one to three grade A embryos were transferred at day 3
fertilization.
The luteal phase support was initiated from the day of oocyte retrieval for all patients with
(Cyclogest 400 mg, Actavis pharmaceutical, UK) vaginal suppositories per day till the day of
serum pregnancy test was done.
Serum β-hCG was performed 14 days after the embryo transfer to confirm chemical pregnancy.
Clinical pregnancy was confirmed when there was an evidence of gestational sac, embryo and
fetal heart activity at time of transvaginal ultrasound evaluation by the 6th week.
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