Pharmacokinetics of Fluconazole in Children (2-18 Years)

Invasive Fungal Infections Clinical Trial

— FOCUS  

Official title:

Pharmacokinetics of Fluconazole Given Orally or Intravenously as Prophylaxis or Therapy to Children and Adolescents With Invasive Fungal Infections

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05130723
• Other study ID #: UMCN-AKF-21.05
• Secondary ID: 2021-006868-24
• Status: Recruiting
• Start date: October 18, 2022
• Est. completion date: October 1, 2023

Study information

• Verified date: October 2022
• Source: Radboud University Medical Center
• Contact: Anouk ME Jansen, PharmD
• Phone: +31650155750
• Email: anouk.me.jansen[@]radboudumc.nl
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

30 pediatric patients aged 2-18 years receiving fluconazole as part of standard care for the treatment or prophylaxis of an invasive fungal infection will be included in the study. Between day 2 and 10, 6 samples will be collected on two days. In the case a patient switches from oral to intravenous therapy, an additional PK-day consisting of 3 samples will be scheduled. Fluconazole plasma concentrations will be determined. A pharmacokinetic model will be fitted to the data from all individuals simultaneously. Data will be analysed using non-linear mixed effects modelling (NONMEM). Monte Carlo simulations will guide the establishment of an improved fluconazole dosing regimen for pediatric and adolescent patients.

Description:

Fluconazole has been available since 1990, however a limited number of studies addressed the pharmacokinetics (PK) of fluconazole in children and adolescent patients. Solid PK data are lacking, despite there being expected variation due to physiological differences with adults likely resulting in significant clinical impact. Especially in the paediatric population where fluconazole is extensively used, including in patients who have moderate to severe renal function disturbances, this information is needed. Therefore, it seems prudent to conduct a study in a cohort of paediatric patients who receive fluconazole as prophylaxis or treatment. The primary objective of the study is to establish an improved fluconazole dosing regimen for paediatric and adolescent patients aged 2-18 years.

A total of pediatric 30 patients will be included in this observational PK-study. Patients will receive standard fluconazole therapy according to (local) protocol. Blood samples will be collected from already placed arterial or central venous catheter.

Between day 2 and 10, six blood samples will be collected for the purpose of PK analysis. Samples will be collected on two different days. On the first PK-day, 3 samples will be collected on t = 0, 1, and 5 hours after fluconazole administration and on the second PK-day, 3 samples will be collected on t = 0.5, 3, and 7 hours after fluconazole administration.

If the patient is expected to switch from iv to oral therapy or vice versa within an additional 30 days, the patient will remain in the study to collect data on absolute oral bioavailability. An additional PK-curve of maximum 3 samples may be drawn.

Plasma concentrations of fluconazole will be measured in all available samples by means of a validated Liquid Chromatography with tandem mass spectrometry (LC-MS-MS) method.

A pharmacokinetic model will be fitted to the data from all individuals simultaneously. Data will be analysed using non-linear mixed effects modelling (NONMEM).After selection of the final model, a simulation study is performed using this model to assess exposure following various dosing regimens.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: October 1, 2023
• Est. primary completion date: October 1, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 2 Years to 18 Years

Eligibility

Inclusion Criteria:

• Subject is treated with fluconazole for prophylaxis or treatment of an invasive fungal infection;

• Subject is 2 - 18 years of age on the day of the first fluconazole dosing

• Subject is managed with a central venous catheter or arterial line from which blood can be obtained.

Exclusion Criteria:

• Subject is managed by means of an extracorporeal clearance technique;

• Subject has previously participated in this study.

Related Conditions & MeSH terms

• Infections
• Invasive Fungal Infections
• Mycoses

Locations

Country	Name	City	State
Netherlands	Radboud University Medical Center	Nijmegen
Netherlands	Prinses Máxima Centrum voor Kinderoncologie	Utrecht

Sponsors (1)

Lead Sponsor	Collaborator
Radboud University Medical Center

Country where clinical trial is conducted

Netherlands, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Target attainment of fluconazole in pediatric patients	Percentage of pediatric patients reaching the predetermined pharmacokinetic/pharmacodynamic (PK/PD) target (an area-under-the-concentration-time-curve (AUC) above 400 mg*h/L)	At steady state: at day 2 after start of fluconazole therapy