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Clinical Trial Summary

Peri-operative opioid administration has long been one of the three pillars of 'balanced anaesthesia',over the span of just a few years,opioids were widely used in perioperative analgesia because of pain as the fifth vital sign.However, opioid administration is not without concern and is associated with many side-effects such as constipation, urinary retention, respiratory depression and postoperative nausea and vomiting .Cleft lip,palate,alveolus are common craniofacial abnormalities and usually require surgical repair.These patients have risks for various perioperative complications due to their young age and craniofacial abnormalities.

This study was designed to compare the effects of opioid based anesthesia(OBA) and opioid free anesthesia(OFA )on perioperative complications in patients with in cleft lip,palate,alveolus surgery, including respiratory depression, postoperative nausea and vomiting, hemodynamic effects, etc.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04081909
Study type Interventional
Source Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Contact Yu Sun, MD,PhD
Phone 0086-136-1189-5542
Email dr_sunyu@163.com
Status Not yet recruiting
Phase Phase 4
Start date September 4, 2019
Completion date October 4, 2020

See also
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Recruiting NCT03162692 - Preoperative Anxiety's Incidence and Related Factors in Surgical Patients N/A