IUGR; Cause and Relationship

Intrauterine Growth Restriction Clinical Trial

Official title: Intra Uterine Growth Retardation;Causes and Relationship

Status Completed

Clinical Trial Summary

Intrauterine growth restriction (IUGR) is a pregnancy complication in about 3-5% of all pregnancies in Sweden. IUGR fetuses are at high risk of morbidity and death. The method used in Sweden to detect IUGR is repeated measurements of pregnant women's symphysis-fundus measure (SF measure).

Weight estimation with ultrasound is performed only on indication; stagnant or deplaning SF dimensions or in the event of complications. Only high-risk pregnancies have repeated growth checks during pregnancy from the beginning.

There are potential benefits to detecting IUGR fetuses during pregnancy. Still, the effect is questioned. A meta-analysis of randomized studies could not benefit from a routine ultrasound in the third trimester.

The scientific purpose of this work is to evaluate the benefits of early detection and care of SGA (small for gestational age)/IUGR (growth-inhibited) fetuses and, if possible, to increase knowledge about this patient group. The hope is that this will lead to a better opportunity to personalize both preventive care and treatment of these women and children.

Clinical Trial Description

Design: Register-based cohort study. Population: All pregnancies in Stockholm from 2014 to 2017 A Composite outcome for the study is constructed and consists of at least one of the following outcomes

1. HIE (hypoxic-ischemic encephalopathy)2-3 (neonatal convulsions in the fetus after childbirth),

2. Intracranial hemorrhage,

3. Apgar score < 4 at 5 minutes,

4. Arterial umbilical cord pH (potential of hydrogen) < 7.10,

5. Intrauterine fetal death, 6)intrapartal death.

Inclusion: All pregnancies in Stockholm with a fetus, born between 2014 and 2017 and without chromosomal abnormalities or other structural abnormalities, will be included in the project. ;

Related Conditions & MeSH terms

• Fetal Growth Retardation
• Intrauterine Growth Restriction

• NCT number: NCT05142644
• Study type: Observational
• Source: Karolinska Institutet
• Status: Completed
• Start date: January 1, 2020
• Completion date: October 30, 2021