Cord Blood Nesfatin-1 and Irisin in the Intrauterine Growth Restricted Fetuses

Intrauterine Growth Restriction Clinical Trial

Official title:

The Association of Cord Blood Nesfatin-1 and Irisin Level With Fetal Doppler Parameters in Pregnancies Complicated With Intrauterine Growth Restricted Fetuses

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03808571
• Other study ID #: 1
• Status: Completed
• Start date: January 1, 2018
• Est. completion date: January 15, 2019

Study information

• Verified date: January 2019
• Source: Yuzuncu Yil University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

: The aim of this study is to investigate Cord blood irisin and nesfatin-1 levels in pregnancies with intrauterine growth retardation and to determine whether they are associated with abnormal fetal doppler findings or not.

Description:

This study was conducted at Yüzüncü Yıl University Medical Faculty Obstetrics and Gynecology Clinic. The study group included 34 pregnant women ranged from 18 to 45 years old who have intrauterine growth retardation and underwent ceseraen section. 32 pregnant women who had no abnormality on prenatal follow-up and underwent elective ceserean seciton served as control group. The maternal age, height, weight, body mass index (BMI), systolic and diastolic blood pressures were recorded in both groups of patients. Maternal serum total blood count and biochemical parameters were obtained from the laboratory parameters. Gestational week at birth, birth weight, sex, 1st and 5th minute APGAR scores were recorded. Blood samples were collected from all the cases during the cesarean section for measurmenet of nesfatin-1 and irisin by doubly clamped umbilical cord. Blood samples were immediately centrifuged in sterile tubes and maintained at -80 ° C until assessed.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 66
• Est. completion date: January 15, 2019
• Est. primary completion date: January 10, 2019
• Gender: Female
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Pregnant women with intrauterine grwoth rectricted fetuses.

• Healthy pregnancies

Exclusion Criteria:

• Pregnant women with chronic medical conditions

• multiple pregnancies

• fetuses with fetal malfomations or genetic syndromes

• pregnant women older than 45 years old

Related Conditions & MeSH terms

• Fetal Growth Retardation
• Intrauterine Growth Restriction
• Irisin
• Nesfatin-1

Intervention

Other:
• cord blood specimen during the delivery
The cord blood will be taken during the delivery of baby.

Locations

Country	Name	City	State
Turkey	Yuzuncu Yil University, Medical faculty, department of obstetric and gynecology	Van

Sponsors (1)

Lead Sponsor	Collaborator
Yuzuncu Yil University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	cord blood nesfatn-1 level measurement	cord blood levels of nesfatin-1 in pregnancies with intrauterine growth restricted fetuses and healthy pregnancies.	9 months
Secondary	Cord blood irisin level measurement	ord blood levels of irisin in pregnancies with intrauterine growth restricted fetuses and healthy pregnancies.	9 months