Intrauterine Growth Restriction Clinical Trial
Intrauterine growth restriction (IUGR) is defined as fetal abdominal circumference (AC) or
estimated fetal weight (EFW) < 10th centile. In asymmetrical IUGR the parameter classically
affected is the abdominal circumference (AC). Fetal growth restriction (FGR) complicates
approximately 0.4% of pregnancies and severely increases the risk of perinatal morbidity and
mortality. This is particularly due to premature delivery, both for fetal and for secondary
maternal indications such as the development of pre-eclampsia.
Consequence of deficient uteroplacental blood flow, including IUGR, pre-eclampsia, and
placental abruption have been implicated in more than 50% of iatrogenic premature births.
For this reason, the problem of severe IUGR forms a substantial portion of the population
that tertiary care centres care for.
The effect of early-onset IUGR is particularly significant: of those born alive, less than a
third will survive their neonatal intensive care unit (NICU) stay without significant
neurodevelopmental sequelae. Survival rates for severely growth-restricted fetuses very
remote from term (<28 weeks' gestation) vary from 7% to 33%.
As these early-onset IUGR children are born very preterm, there are significant risks of
neonatal mortality, major and minor morbidity, and long-term health sequelae.
The use of ultrasound Doppler waveform analysis in pregnancies complicated by IUGR suggests
compromised uteroplacental circulation and placental hypoperfusion. Currently there are no
specific evidence-based therapies for placental insufficiency and severe IUGR. Non-specific
interventions include primarily lifestyle modifications, such as reducing or stopping work,
stopping aerobic exercise, rest at home, and hospital admission for rest and surveillance.
These interventions, which are not supported by evidence from randomized trials, are used in
the belief that rest will enhance the uteroplacental circulation at the expense of that to
the glutei and quadriceps muscles.
There is evidence from ex vivo and animal models of growth restriction that the
phosphodiesterase 5 inhibitor sildenafil citrate increases average birth weight and improves
uteroplacental blood flow (umbilical artery, uterine artery).
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04506970 -
Predicting Placental Pathologies by Ultrasound Imaging
|
||
Recruiting |
NCT03866863 -
Intra Uterine Growth Restriction
|
||
Recruiting |
NCT03662178 -
Investigating the Structured Use of Ultrasound Scanning for Fetal Growth
|
||
Not yet recruiting |
NCT05720169 -
Fetal, Obstetrics and Reproduction Genomics
|
||
Completed |
NCT04633551 -
Vascular Inflammation and Anti-inflammatory Supplements After Adverse Pregnancy Outcomes
|
N/A | |
Recruiting |
NCT05500989 -
PlacEntal Acute Atherosis RefLecting Subclinical Atherosclerosis
|
||
Recruiting |
NCT04141189 -
Comparison of Follow-up Protocols in Terms of Fetal, Neonatal and Maternal Results in Intrauterine Growth Retardation
|
N/A | |
Completed |
NCT03726697 -
Effect of Tahneek on Hypoglycemia in Newborn Infants
|
N/A | |
Recruiting |
NCT03398629 -
Diagnosis and Management of Intrauterine Growth Restriction and Congenital Anomalies
|
||
Recruiting |
NCT02473991 -
Correlation Between Placental Thickness in the Second and Third Trimester and Fetal Weight
|
N/A | |
Completed |
NCT02696577 -
The Effect of Omega 3 on Pregnancy Complicated by Asymmetrical Intrauterine Growth Restriction
|
Phase 2 | |
Recruiting |
NCT04766866 -
sFlt1/PlGF and Planned Delivery to Prevent Preeclampsia at Term.
|
N/A | |
Terminated |
NCT04047966 -
Study of the Fetal and Maternal Microbiota in Preganant Women With Fetal Defect Growth
|
||
Not yet recruiting |
NCT03865628 -
Ultrasound Evaluation of Fetal Hemodynamics and Perinatal Complications
|
||
Completed |
NCT05328453 -
Sonographic 3D Measurement of Fetal Thymus May be Used to Predict the Small Baby in Pregnancy.
|
||
Completed |
NCT05800938 -
The Effect of Oral Isosorbide Mononitrate Therapy on Umbilical Artery Doppler Resistance Index in Pregnancies With Intrauterine Growth Restriction: Prospective Randomized Control Trial
|
Phase 4 | |
Not yet recruiting |
NCT06226051 -
Growing Little PEAPODS Study
|
||
Recruiting |
NCT02807324 -
Women Specific Cardiac Recovery After Preeclampsia
|
||
Recruiting |
NCT02515292 -
Evaluation of Infants With Intrauterine Growth Restriction
|
N/A | |
Active, not recruiting |
NCT01942525 -
Influence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants
|
N/A |