Intraoperative Anuria Clinical Trial
Official title:
Perioperative Relevance of Intraoperative Anuric Episodes Within a Goal-directed Haemodynamic Algorithm in Patients Undergoing Laparotomy Due to Epithelial Ovarian Cancer
A single-center prospective observational study. This study examines urine flow and
haemodynamic parameters during abdominal surgery and analyses the association to
postoperative renal function and markers and to postoperative clinical outcome.
Primary hypothesis:
• Within a goal-directed haemodynamic protocol during gynecologic cancer surgery there are
phases of temporary anuria.
Secondary hypothesis:
- Perioperative anuric phases are directly associated to the postoperative increase of
NGAL (neutrophil gelatinase-associated lipocalin) and creatinine
- Perioperative renal dysfunction is directly associated to postoperative complications
and functional recovery of patients
- A response of urine flow to a standardized postoperative diuretic bolus can identify
patients who benefit from a pharmaceutical fluid mobilization
- Within a goal-directed haemodynamic protocol during gynaecologic cancer surgery, the
methods for the measurement of stroke volume of the heart differ
n/a
Observational Model: Cohort, Time Perspective: Prospective