Intraocular Pressure Clinical Trial
Official title:
The Effect of Different Concentrations of Sevoflorane on Intraocular Pressure in Children Undergoing Ocular Surgery Under General Anesthesia
One important goal in anesthetic management during ocular surgery is to provide adequate
control of intraocular pressure (IOP). An increase in IOP may be catastrophic in patients
with glaucoma or a penetrating open-eye injury. Accurate assessment of IOP is particularly
important in infants and children with definite or suspected glaucoma undergoing examination
under anesthesia.
Anesthetic regimens in this surgical field commonly consist of short-acting anesthetic
agents, such as sevoflurane. Sevoflurane is known to reduce the IOP. During pediatric ocular
surgery, the inspired sevoflurane concentration varies continuously and may have an impact
over the IOP that could affect the conduct of surgery. In this study the investigators wish
to evaluate whether variations in sevoflurane concentration do affect the IOP.
Status | Not yet recruiting |
Enrollment | 21 |
Est. completion date | June 2011 |
Est. primary completion date | April 2011 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A to 18 Years |
Eligibility |
Inclusion Criteria: - children with healthy eyes, undergoing elective surgery for strabismus correction or tear duct probing and irrigation. Exclusion Criteria: - children with adverse reaction or contraindication (of any other reason) to sevoflurane or remifentanil, and patients with pre-existing intra-ocular ophthalmic disease, or infection. |
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Basic Science
Country | Name | City | State |
---|---|---|---|
Israel | Tel-Aviv Sourasky Medical Center | Tel Aviv |
Lead Sponsor | Collaborator |
---|---|
Tel-Aviv Sourasky Medical Center |
Israel,
1) Artru, A.A. and Y. Momota, Trabecular outflow facility and formation rate of aqueous humor during anesthesia with sevoflurane-nitrous oxide or sevoflurane-remifentanil in rabbits. Anesth Analg, 1999. 88(4): p. 781-6. 2) Blumberg, D., et al., The effects of sevoflurane and ketamine on intraocular pressure in children during examination under anesthesia. Am J Ophthalmol, 2007. 143(3): p. 494-9. 3) Murphy, D.F., Anesthesia and intraocular pressure. Anesth Analg, 1985. 64(5): p. 520-30. 4) Sator, S., et al., Desflurane maintains intraocular pressure at an equivalent level to isoflurane and propofol during unstressed non-ophthalmic surgery. Br J Anaesth, 1998. 80(2): p. 243-4. 5) Sator-Katzenschlager, S., et al., Sevoflurane and propofol decrease intraocular pressure equally during non-ophthalmic surgery and recovery. Br J Anaesth, 2002. 89(5): p. 764-6. 6) Rosenbaum AL, S.A., Clinical Strabismus Management: Principles and Surgical Techniques. 1999, Philadelphia.
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | IOP | IOP will be measured in both eyes, after induction of anesthesia and before the onset of surgery | first hour of anesthesia | No |
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