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Clinical Trial Summary

QTc prolongation and premature ventricular contractions (PVCs) are common in hemodialysis (HD) patients and are associated with sudden cardiac death. It is known that higher dialysate bicarbonate is associated with more QTc prolongation during HD sessions. This study aims to assess the effects of lower (30 mEq/L) versus higher (35 mEq/L) dialysate bicarbonate in adult maintenance HD patients admitted to the hospital. The investigators will randomly assign subjects to lower versus higher dialysate bicarbonate concentrations during their hospital stay for up to a maximum of six HD sessions or until their hospital discharge.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05814146
Study type Interventional
Source Brigham and Women's Hospital
Contact Katherine S Ravi, MD, MPH
Phone (617) 732-6383
Email ksravi@bwh.harvard.edu
Status Recruiting
Phase N/A
Start date August 24, 2023
Completion date October 1, 2026

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